Cure Parkinson's disease! ? Relationship between REM sleep and schizophrenia

Hello. This is Tenmei Watanabe from Seito Medical School. This time, it's a continuation of Parkinson's disease. Let's proceed by assuming that Parkinson's disease is NREM sleep and schizophrenia is REM sleep.

In the previous article, we showed that Parkinson's disease is characterized by low blood pressure, hypothermia, and parasympathetic predominance. In fact, during sleep, during non-REM sleep, the parasympathetic nervous system is dominant, and body temperature tends to be lower than when awake, and many similarities can be found between Parkinson's disease and non-REM sleep.

On the other hand, schizophrenia has high blood pressure and high body temperature, and is dominated by the sympathetic nervous system. Even during REM sleep, when you dream, your body temperature is higher than during non-REM sleep, and the sympathetic nervous system is dominant, so you can say that you are in a state of tension.

The heart rate is high during REM sleep, and it is also high in schizophrenia, but this state of high body temperature and high heart rate is very important when symptoms of schizophrenia such as hallucinations and auditory hallucinations occur. This is an important factor.

In other words, the state of dreaming is accompanied by hallucinations and auditory hallucinations, and it is the difference between being awake and dreaming, and sleeping and dreaming.

Febrile delirium, which causes symptoms such as hallucinations due to high fever, also occurs when the body temperature is high and the heart rate is high. Furthermore, when smoking cannabis, there is a noticeable increase in heart rate, and in severe cases, symptoms such as hallucinations appear.

Schizophrenia, fever delirium, and drug addiction all cause similar symptoms such as hallucinations due to increased heart rate and large amounts of dopamine released.

During REM sleep, your heart rate and breathing rate increase, and your breathing becomes shallow. This is exactly the reaction when the sympathetic nervous system is dominant.

During non-REM sleep, heat release increases, sweating occurs, and body temperature decreases. It can be said that this is when the parasympathetic nervous system is dominant.

Activities that release dopamine include eating sugar, staying up all night, and meditating. There is no problem if taken in moderation, but if these are combined, symptoms of schizophrenia may appear.

These actions increase your heart rate and raise your blood pressure. In other words, the sympathetic nervous system is dominant.

When the sympathetic nervous system becomes dominant, cardiac muscle contraction increases, heart rate increases, and peripheral nerves throughout the body contract. When the parasympathetic nervous system is dominant, the opposite effect occurs.

There is a heart in the heart. In the past, people believed that the heart was in the heart. In modern times, it is common knowledge that humans use their brains to think and feel things.

However, heart rate and even blood flow may control human sensations. When the heart rate increases and blood flow increases, the metabolism of various substances in the body becomes active. It may be said that the reason why something that does not normally exist in front of our eyes appears in front of our eyes as a hallucination depends on the blood flow rate of the heart.

On the other hand, Parkinson's disease is exactly the opposite of schizophrenia, so it may be a good idea to think about what I have described so far in the opposite way.

Parkinson's disease has the same symptoms as non-REM sleep, with low blood pressure and low heart rate dominated by the parasympathetic nervous system. There is also less blood flow, so as mentioned in the previous article, you will probably experience symptoms such as trembling in your hands in response to the cold.

Furthermore, if you explore the information that the amygdala becomes active during REM sleep and its relationship with peripheral nerves, you may come across some interesting facts.

I would like to explore this area as a future issue. It may be possible to broadly divide diseases and diseases into two types based on whether the sympathetic nervous system is dominant or the parasympathetic nervous system is dominant. that's all. See you soon.

Symptoms of Parkinson's disease are the same as reactions to cold weather in winter! ?

Hello. This is Tenmei Watanabe from Seito Medical School. This time, as a medical school report, I would like to research Parkinson's disease and its treatment methods.

Parkinson's disease presents with movement disorders, such as tremors in the hands and difficulty moving or walking. Although it is considered to be a progressive neurodegenerative disease, onset is most common in middle-aged people over 40 years of age, especially in people over 65 years of age. (Quoted from Family Medicine)

Some of the symptoms of Parkinson's disease are similar to how humans react to the cold in winter.

In Japan, it is said to be caused by damage to dopamine neurons in the substantia nigra. Conditions other than Parkinson's disease that have similar symptoms are called Parkinson's syndrome. Dementia often develops as a secondary disease to Parkinson's disease.

Parkinson's disease is a disease caused by a lack of dopamine, and schizophrenia is a disease caused by an excess of dopamine.

Let's make an assumption here.

Hypothetically, a deficiency in metabolism is associated with Parkinson's disease, and an increased metabolism is associated with schizophrenia. In other words, it can be divided into Parkinson's disease, which is dominated by the parasympathetic nervous system, and schizophrenia, which is dominated by the sympathetic nervous system.

Parkinson's disease causes low blood pressure, low body temperature, and poor metabolism. I have symptoms similar to a reaction to enduring the winter cold, and I don't sweat enough. Blood vessels dilate, body temperature falls, and because the parasympathetic nervous system is dominant, patients often have problems such as frequent urination.

Parkinson's disease symptoms are caused by an illusion of thermoregulation, such as the winter cold. Because there is not enough amino acids, there is no metabolism and body temperature does not rise.

On the other hand, people with schizophrenia have high blood pressure, high body temperature, and a fast metabolism. My mental health often worsens in the summer, and I sweat excessively. Blood vessels constrict, body temperature rises, and the sympathetic nervous system predominates. The positive symptoms of schizophrenia correspond to manic depression, and the negative symptoms correspond to depression. The difference is whether there are temporary stable symptoms.

"In some cases, dementia affects the autonomic nervous system that regulates sweating and blood volume, making it difficult to regulate body temperature. For example, in Lewy body dementia (*1), symptoms include excessive sweating, night sweats, and dilated blood vessels in the skin. However, increased sweat and blood flow unrelated to ambient temperature can lower body temperature and cause hypothermia.

(https://www.citizen-systems.co.jp/health/column/article/article_10.html）

The above quotation is consistent with the vasodilation and hypothermia of Parkinson's disease, and the symptoms of Parkinson's disease patients include excessive sweating in the upper body and less sweating in the lower body, so it may be similar to Lewy body dementia. seems to be related to abnormalities in the autonomic nervous system.

The future challenge is to explore the possibility of Parkinson's disease from the negative side of schizophrenia and the positive side of dementia, which are the opposite of Parkinson's disease.

The cause of hyperhidrosis was a disturbance in the autonomic nervous system! ? The key is sorbitol, which is a form of glucose! !

Hello. This is Tenmei Watanabe from Clear File Seito Medical School. This is an article about my research results regarding hyperhidrosis. Hyperhidrosis is a disease that causes excessive sweating all over the body, limbs, etc. Working in sweat is definitely not hyperhidrosis, so be sure to check it out! !

First, let's look into heat rash, hidradenitis suppurativa, armpits, and anhidrosis, which are diseases that produce sweat similar to hyperhidrosis. I would like to look into family medicine, a medical strategy book that is too thick for elementary school students and cannot be compared to game strategy books.

<<Prickly heat: Similar disease: Not an autoimmune disease>>

Sweat glands are most active in infants. It occurs when the outlet of the eccrine glands that regulate body temperature become clogged due to heat and humidity.

<<Hidradenitis suppurativa: Similar disease: May be an autoimmune disease>>

It occurs when the sweat glands become suppurated. It will heal once the pus comes out.

<<Armpit: Similar disease: Not an autoimmune disease>>

Refers to smelly sweat in the armpits. It is caused by a mixture of bacteria on the skin and sweat.

<<Anhidrosis: Similar diseases>>

Sweat may not be produced in one part of the body, or the whole body may not produce sweat. The inability to sweat is caused by abnormalities in the eccrine glands that regulate body temperature or the nerves related to the eccrine glands.

Let's look at the commonalities of heat, tension, high fever, Graves' disease, and diabetes, which are secondary diseases of hyperhidrosis.

<<Graves' disease: Secondary disease: Autoimmune disease>>

Symptoms include swelling of the thyroid gland, palpitations, and facial changes such as eyes protruding. It also makes you sweat. Antibodies are produced that bind to thyroid-stimulating hormone receptors and stimulate the thyroid gland. Graves' disease is an autoimmune disease that causes abnormalities in immune function.

<<Diabetic neuropathy: secondary disease, autonomic imbalance>>

In diabetic neuropathy, problems occur in peripheral nerves that spread throughout the body. Damage to the autonomic nervous system causes symptoms such as abnormal sweating. The cause is that sorbitol, which is converted from excessive glucose intake, accumulates in nerve cells, or that end products of glycation accumulate. Treatment drugs include aldose reductase inhibitors.

Based on the conclusion so far, I feel that the idea that hyperhidrosis is due to autonomic nervous system imbalance is the closest to the answer. Graves' disease is also an autoimmune disease, but if it is related to autonomic nervous system imbalance, we can see that they are both secondary to hyperhidrosis and are the cause of the same disease.

★Confirmed tasks and assumptions below★

(★Task 1) Investigate heat rash, hidradenitis suppurativa, armpits, and anhidrosis

(★Task 2) Investigate heat rash, tension, high fever, and anhidrosis, which are secondary diseases of hyperhidrosis. Find commonalities between Graves' disease and diabetes

(★Hypothesis 1) Perhaps some kind of chemical substance, such as heat or stress, is being released.

(★Hypothesis 2) Hyperhidrosis is not an autoimmune disease but an autonomic nervous disorder.

☆The following are unconfirmed issues and assumptions☆

(Assignment 3) One of the treatments is to cut the sympathetic nerves in the armpits, so let's research this

(Assignment 4) Research the sweat glands and eccrine glands in Wiki and medical books

( Question 5) What is the difference between peripheral nerves and autonomic nerves?

(Question 6) What is the relationship between foods containing a lot of sorbitol and diseases related to hyperhidrosis and autonomic imbalance? Find out about aldose reductase inhibitors

(Point 1) Abnormalities in the eccrine glands that regulate body temperature and the nerves that connect to the nerves

(Point 2) Graves' disease is an autoimmune disease, and are related diseases also autoimmune diseases

(Look it up on Wiki) Hyperhidrosis syndrome, prickly heat, hidradenitis suppurativa, armpits, anhidrosis, Graves' disease, diabetes, sweat glands, eccrine glands

(hypothesis 3) Diabetic neuropathy causes damage to peripheral nerves, and one of the symptoms is abnormal sweating. Hyperhidrosis may also be caused by a problem with peripheral nerves.

You may freely copy and paste articles from this blog as long as you provide a link

Hello. This is Tenmei Watanabe from Seito Medical School. Below is the pre-rewrite article.

plagiarism. Sometimes it makes the news. A university professor cheated on his thesis. If he sees a similar article on his blog, he may suspect plagiarism. Fortunately, I have probably never been plagiarized until now.

I think many people feel angry when they find out that their work has been plagiarized. I also don't feel at ease when someone uses my articles as their own, even though I didn't give them permission. However, not many people have ever thought about the psychology of those who plagiarize.

If it's a blog, it's plagiarism, so at least people are reading my blog. On top of that, the people who plagiarize can be said to be fans of the content of the people whose content is being plagiarized, because the plagiarized articles are so attractive that they are willing to take the risk to use them without permission.

Here, you can see that instead of talking about plagiarism as a story about something bad done, it is better to guide the plagiarism in a good way as a colleague. For example, if you discover that your work has been plagiarized, you can contact the person who plagiarized the work and ask them to link to your site.

If you have any other concerns, please feel free to point them out and have them improve. For example, if you tell them that it's okay to copy and paste, but not to modify, there's a good chance they'll restore the changes you made. Since there is a link on it, if you think that it is working for advertising, it will be beneficial for you as well.

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If you were to plagiarize, who would you plagiarize from? It's human nature to want to plagiarize content from someone you admire who creates content you like.

Therefore, instead of making unnecessary trouble, if you give them permission to use the game as long as they follow the rules, like a franchise, you can prevent them from losing their precious core fans.

I will claim copyright on this blog, but as long as you post a link, I don't mind people copying and pasting it without my permission. This is because, although I may try it out, I would like to attract customers with my blog and sell e-books, USB memory, etc., rather than posting advertisements and earning income.

The only cost for e-books is the electricity bill and a certain percentage of the fees, so I think it would be okay to sell them for 400 yen or something. Many USB flash drives can now be purchased for less than 1,000 yen, and I would like to sell it for less than 2,000 yen including shipping.

As those who read this blog will understand, my blog seems to contain a large amount of information, and is like a large burger. The prices for e-books and USB memory are unbeatable, so I would like to include useful data.

As long as I know that I am the author, I don't mind if other people copy and paste my articles on their blogs. Of course, as I have said repeatedly, I would like you to be sure to link to our blog.

As long as you post a link, you can of course tell me about it, but I don't think it's a problem if people copy and paste articles from this blog onto other sites without my permission.

In this blog called Seito Medical School Clear File, I'm going to write that you can copy and paste it anywhere you can see it in the blog, so please use it if you like.

This time it was a rewritten article, but it was about my recent movements. If you are having trouble selling USB memory, I would be grateful if you could give me some advice. It would be good if we could separate the cases by selling USB memory by mail to people living in Japan, and e-books to people living overseas.

That's all about my ideas for now. Let's meet again! ! See you soon.

In most (3a+5b) prime numbers, 3, a, 5, and b are relatively prime, and at least one of (a) and (b) has a prime value. by Nada 20231108

Hello. This is Nada from Seito Medical School. The graph below is about prime numbers. This is a numerical example when 3a+5b. If a is a multiple of 5, it becomes 3x5xa+5xb, so it is a multiple of 5 and is not a prime number. Similarly, if b is a multiple of 3, it becomes 3a+5x3xb, which is a multiple of 3 and therefore not a prime number. Also, in a diagonal direction from the prime numbers a and b, the color of the graph advances to the squares diagonally below the prime numbers a and b, but by also advancing to the squares diagonally above, all prime numbers can be covered. From this, 3a+5b is a prime number if at least one of a and b is a prime number, and exceptionally when a of 3a is a multiple of 3 or b of 5b is a multiple of 5. I understand. For example, the diagonally upper row of a=5 is 17, 19, 21, 23. Similarly, the numbers diagonally above a=7 are 23, 25, 27, 29, 31, 33. This leads to the law of prime numbers. Most 3a+5b prime numbers have 3, a, 5, and b relatively prime, and at least one of a and b has a prime value. By the way, mutually prime means that they have no common divisors. My future challenge will be to expand on this and investigate the law of appearance of twin prime numbers.

a\b 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19

1 8 13 18 23 28 33 38 43 48 53 58 63 68 73 78 83 88 93 98

2 11 16 21 26 31 36 41 46 51 56 61 66 71 76 81 86 91 96 101

3 14 19 24 29 34 39 44 49 54 59 64 69 74 79 84 89 94 99 104

4 17 22 27 32 37 42 47 52 57 62 67 72 77 82 87 92 97 102 107

5 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95 100 105 110

6 23 28 33 38 43 48 53 58 63 68 73 78 83 88 93 98 103 108 113

7 26 31 36 41 46 51 56 61 66 71 76 81 86 91 96 101 106 111 116

8 29 34 39 44 49 54 59 64 69 74 79 84 89 94 99 104 109 114 119

9 32 37 42 47 52 57 62 67 72 77 82 87 92 97 102 107 112 117 122

10 35 40 45 50 55 60 65 70 75 80 85 90 95 100 105 110 115 120 125

11 38 43 48 53 58 63 68 73 78 83 88 93 98 103 108 113 118 123 128

12 41 46 51 56 61 66 71 76 81 86 91 96 101 106 111 116 121 126 131

13 44 49 54 59 64 69 74 79 84 89 94 99 104 109 114 119 124 129 134

14 47 52 57 62 67 72 77 82 87 92 97 102 107 112 117 122 127 132 137

15 50 55 60 65 70 75 80 85 90 95 100 105 110 115 120 125 130 135 140

16 53 58 63 68 73 78 83 88 93 98 103 108 113 118 123 128 133 138 143

17 56 61 66 71 76 81 86 91 96 101 106 111 116 121 126 131 136 141 146

18 59 64 69 74 79 84 89 94 99 104 109 114 119 124 129 134 139 143 149

19 62 67 72 77 82 87 92 97 102 107 112 117 122 127 132 137 142 147 152

I tried to solve Fermat's last theorem! A legendary conundrum that remained unsolved for 350 years. by 天風 20231106

axa+bxb=cxc has an answer of 3×3+4×4=5×5, for example. However, Fermat's argument was that expressions with powers greater than axaxa+bxbxb=cxcxc, axaxaxa+bxbxbxb=cxcxcxc, and more do not have integer answers.

``It is impossible to divide a cubic number into two cubic numbers, or a 4th power into two 4th powers, and in general into the same power for any higher power than the 2nd power. I have discovered a truly amazing proof, but this space is too small to contain it.'' (The First Number Theory, Joseph H. Silverman)

In 1994, Andrew Wiles published a proof that all semistable elliptic curves with rational coefficients are modular. As a result, Fermat's prediction made 350 years ago became a reality.

(*) From here, I would like to write down the proof that I performed myself.

a^n+b^n=c^n (here, a^n means a is multiplied n times. If a^3, it is the same as axaxa) b^n=c^na^n

(Set as a=cd)

b^n=c^n-(cd)^n

=c^nc^n+du (Here, set (cd)^n=c^n-du)

b^n= du

If b=d then b^(n-1)=u

but d^(n-1)≠u

As a hint, a^3+b^3=(a+b)(a^2-ab+b^2), so (a^2-ab+b^2)≠(a+b)^2. Similarly, a^4+b^4 and a^5+b^5 do not become c^4 or c^5.

The simplest form of life is a plastic filtration device. The human body is made up of a huge filtration device. by 天風 20231106

Hello. This is Ryota from Seito Medical School. This time, I would like to delve deeper into what life is.

Life is like a water filter. The water flowing from above circulates inside the device, making it cleaner. The liquid called water stimulates the device, and it can be said that the water becomes cleaner due to this action. If a person applies an external stimulus to the end of the filtration device by turning on the faucet, water will come out of the faucet and the person will drink that water. To do this, the prerequisite is that the water to be filtered is located at a high place, and moves downward toward its destination inside a box called a filtration device, consuming potential energy. The destination means clean water will enter the mouth of the person at the bottom. Because of gravity, non-electric devices like this can carry out life activities. If we consider the filtration device and humans to be one living entity, humans will pour the water they drink into the filtration device from above. Even if the water is a little dirty, it is filtered so it becomes clean. The filtration device can be made of plastic, but water flows from top to bottom inside the box due to gravity, and while the various functions inside the device work, the externally stimulated person drinks the water. This function allows even plastic devices to perform the same functions as life, even without electric power, as long as there is gravity. In other words, the existence of gravity also makes us feel the existence of life.

Readers who have read this far may be wondering. Plastic filtration devices do not split and will stop working once the water that collects at the top is gone. Now, let's think of the human body as a giant filtration device. However, since this is an ``answer'', I will not write any thoughts on it. Learn to arrive at the answer yourself. I hope the answer really represents reality.

Up to here for this time. See you soon.