What is the relationship between the autism spectrum and the autonomic nervous system? ? Is intellectual disability dominated by the sympathetic nervous system or by the parasympathetic nervous system? ?

Hello. I am Tenmei Watanabe from Seito Medical School Clear File. This time, I am writing a medical report. I would like to think about the treatment for Kleefstra syndrome, a disease that only a few hundred people in the world suffer from, as seen in a news article.

Kleefstra syndrome is a disease caused by the absence of one gene, and is a relatively new disease that was discovered in 2000. Kleefstra syndrome is one of the diseases designated as intractable diseases, and has a variety of symptoms, including developmental delay, intellectual disability, distinctive facial features, hypotonia in infancy, and congenital disorders.

Here, similar examples of developmental delay, intellectual disability, and characteristic facial features include autism spectrum disorder and intellectual disability.　　

Autism spectrum disorder often occurs together with depression, and each illness can be said to be a state in which the parasympathetic nervous system is dominant in the autonomic nervous system.

The following three symptoms are listed in "Family Medicine" as symptoms of childhood autism.

The following is an excerpt from Family Medicine.

① Communication disorder in which people are unable to communicate with friends and those around them due to language delay

② Social disorder in which they are unable to perceive the atmosphere of the scene

③ Imagination disorder in which they become absorbed in their favorite things such as trains or building blocks and are unable to focus on anything else

Risperidone CH is one of the prescription drugs for autism spectrum disorder. Risperidone CH is also a prescription drug for schizophrenia, and it can be used as a prescription drug if the sympathetic nervous system is dominant.

However, a contradiction arises. If Risperidone CH is effective for autism spectrum disorders, it can be inferred that the "sympathetic nervous system" is dominant in autism spectrum disorders. If we reread the above text, we can infer that the "parasympathetic nervous system" is dominant in autism spectrum disorders, since depression is often a secondary illness in autism spectrum disorders.

In autism spectrum disorders, is the sympathetic nervous system dominant because Risperidone CH is effective, or is the parasympathetic nervous system dominant because depression also occurs? The answer is one of the two.

So, based on what we have seen so far, the dichotomy of the autonomic nervous system that I propose divides various illnesses into those that are sympathetic dominant and those that are parasympathetic dominant, but the question is whether there is a clear relationship between IQ and the autonomic nervous system.

If autism spectrum disorder is a parasympathetic nervous system dominant disease, is there a correlation between lower than average intelligence and this parasympathetic nervous system dominance? Conversely, if the sympathetic nervous system is dominant, the IQ should tend to be higher.

From my current perspective, I predict that autism spectrum disorder is caused by a dominance of the parasympathetic nervous system. I would like to investigate the relationship with various other diseases a little more before reaching a conclusion. What do you all think? Well then.